Skip Navigation



Glycobiology Advance Access published online on August 22, 2008
Glycobiology, doi:10.1093/glycob/cwn076
This Article
Right arrow Advance Access manuscript (PDF) Freely available
Right arrow All Versions of this Article:
18/11/832    most recent
cwn076v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Schorey, J. S.
Right arrow Articles by Sweet, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Schorey, J. S.
Right arrow Articles by Sweet, L.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2008. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Review

The Mycobacterial Glycopeptidolipids: structure, function and their role in pathogenesis

Jeffrey S. Schorey* and Lindsay Sweet

Department of Biological Sciences, Eck Institute for Global Health and Infectious Diseases University of Notre Dame, Notre Dame, Indiana, 46556

* Corresponding author. Mailing address: Department of Biological Sciences, University of Notre Dame, 130 Galvin Life Science Center, Notre Dame, Indiana, 46556. Phone: (574) 631-3734. Fax: (574) 631-7413. e-mail: Schorey.1{at}nd.edu

Received on April 7, 2008; accepted on August 5, 2008

Glycopeptidolipids (GPLs) are a class of glycolipids produced by several non-tuberculosis-causing members of the Mycobacterium genus including pathogenic and non-pathogenic species. GPLs are expressed in different forms with production of highly antigenic, typeable serovar-specific GPLs in members of the Mycobacterium avium complex (MAC). M. avium and M. intracellulare, which comprise this complex, are slow-growing mycobacteria noted for producing disseminated infections in AIDS patients, and pulmonary infections in non-AIDS patients. Previous studies have defined the gene cluster responsible for GPL biosynthesis and more recent work has characterized the function of the individual genes. Current research has also focused on the GPLs’ role in colony morphology, sliding motility, biofilm formation, immune modulation and virulence, and along with recent advances in our understanding of GPL biosynthesis is the subject of this review.

Key words: biofilm / GPL / morphology / mycobacteria / review


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.