Skip Navigation



Glycobiology Advance Access published online on June 5, 2008
Glycobiology, doi:10.1093/glycob/cwn051
This Article
Right arrow Advance Access manuscript (PDF) Freely available
Right arrow All Versions of this Article:
18/9/719    most recent
cwn051v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Marino, J. H.
Right arrow Articles by Teague, T. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Marino, J. H.
Right arrow Articles by Teague, T. K.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2008. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Disruption of Thymopoiesis in ST6Gal I Deficient Mice

Julie H. Marino1, Chibing Tan1, Brenda Davis1, Eun-Soo Han4, Morgan Hickey4, Rebecca Naukam1, Ashlee Taylor1, Kenton S. Miller4, C. Justin Van De Wiele1 and T. Kent Teague1,2,3*

1 Department of Surgery, University of Oklahoma College of Medicine, Tulsa, Oklahoma, 74135, USA
2 Department of Pharmaceutical Sciences, University of Oklahoma College of Pharmacy, Tulsa, Oklahoma 74135
3 Department of Biochemistry and Microbiology, Oklahoma State University Center for Health Sciences, Tulsa, 74127, USA
4 University of Tulsa, Department of Biological Sciences, Tulsa, Oklahoma, 74104, USA

* To whom correspondence should be addressed: T. Kent Teague, Fax Number – (918)660-3928, Phone Number – (918)660-3920, Email Address – kent-teague{at}ouhsc.edu

Received on March 31, 2008; accepted on May 28, 2008

Thymocyte development is accompanied by sequential changes in cell surface glycosylation. For example, medullary thymocytes have increased levels of {alpha}2,3-linked sialic acid and a loss of asialo core 1 O-glycans as compared to cortical thymocytes. Some of these changes have been linked to fine tuning of the T cell receptor avidity. We analyzed ST6Gal I transcript abundance and levels of {alpha}2,6-linked sialic acid across thymocyte subsets. We found that ST6Gal I transcript levels increased following T cell receptor β-selection suggesting this sialyltransferase may influence the development of early thymocyte populations. Indeed, low levels of {alpha}2,6 linked sialic acid were found in the earliest T lineage cells which then increased in T cell receptor β-selected cells. To determine whether ST6Gal I influences T cell development, we analyzed ST6Gal I-deficient mice for disruptions in thymocyte populations. We found reduced thymic cellularity in the ST6Gal I-deficient mice starting in the early thymocyte compartments.

Key words: Sialic Acid / ST6Gal I / Thymocyte Development


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 JEMHome page
A. Cariappa, H. Takematsu, H. Liu, S. Diaz, K. Haider, C. Boboila, G. Kalloo, M. Connole, H. N. Shi, N. Varki, et al.
B cell antigen receptor signal strength and peripheral B cell development are regulated by a 9-O-acetyl sialic acid esterase
J. Exp. Med., January 16, 2009; 206(1): 125 - 138.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.