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Glycobiology Advance Access published online on May 28, 2008
Glycobiology, doi:10.1093/glycob/cwn046
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© The Author 2008. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Communications

Human and Mouse Macrophage-Inducible C-type Lectin (Mincle) bind Candida albicans

Andrea Bugarcica, Kelly Hitchensb, Anthony G. Beckhouseb, Christine A. Wellsb, Robert B. Ashmanc and Helen Blancharda,*

a Institute for Glycomics, Griffith University, Gold Coast Campus, Queensland 4222, Australia
b National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Queensland 4111, Australia.
c School of Dentistry, The University of Queensland, Brisbane, QLD 4072, Australia.

* Address for correspondence: Dr. Helen Blanchard, Institute for Glycomics, Griffith University, Gold Coast Campus, Queensland 4222, Australia. Phone: +617 555 27023, Fax: +617 555 28098. E-mail: h.blanchard{at}griffith.edu.au.

Received on March 26, 2008; accepted on May 21, 2008

Candida albicans is a causative agent in mycoses of the skin, oral cavity and gastrointestinal tract. Identification of receptors, and their respective ligands, that are engaged by immune cells when in contact with C. albicans is crucial for understanding inflammatory responses leading to invasive candidiasis. Mincle is a recently identified macrophage-expressed receptor that is important for host responses to C. albicans. The carbohydrate-recognition domain of human and mouse Mincle were expressed, purified under denaturing conditions and successfully refolded. In addition to oligomers, there are isolatable monomeric and dimeric forms of the protein that occur under two different buffer solutions. The human and mouse homologues bound yeast extract, and the isolated dimeric and monomeric species also demonstrated recognition of whole C. albicans yeast cells. The data is indicative of several functional states mediating the interaction of Mincle and yeast at the surface of the macrophage.

Key words: Candida albicans, C-type lectin / Mincle / receptor-binding assay


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