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Glycobiology Advance Access published online on August 23, 2007
Glycobiology, doi:10.1093/glycob/cwm089
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© The Author 2007. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions.org

Review

Celebrating the golden anniversary of the discovery of bacillosamine, the diamino sugar of a Bacillus*

Nathan Sharon

Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot 76100, Israel

Phone: 972-8-934-3605, Fax: 972-8-946-8256 Email: nathan.sharon{at}weizmann.ac.il

Received on August 1, 2007; accepted on August 13, 2007

Bacillosamine (2,4-diamino-2,4,6-trideoxy-D-glucose), a rare amino sugar, was discovered fifty years ago as a result of the follow up of a chance observation made during studies of polypeptide synthesis by a Bacillus subtilis strain later renamed Bacillus licheniformis. In the following decades this amino sugar was almost completely ignored, although it was found in a number of bacterial polysaccharides and other metabolites. Recently there has been a burst of interest in bacillosamine when it was found to be a link glycan in eubacterial glycoproteins. In this retrospective, I review the chance discovery of bacillosamine, its structural determination and its biosynthesis.

*Dedicated to Roger W. Jeanloz, mentor and friend, and glycobiology pioneer, in whose laboratory and under whose guidance I discovered bacillosamine, on the occasion of his 90th birthday, November 3, 2007.


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