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Glycobiology Advance Access published online on May 23, 2007
Glycobiology, doi:10.1093/glycob/cwm053
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© The Author 2007. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Anti-asthmatic potential of a D-galactose binding lectin from Synadenium carinatum latex

Alexandre P. Rogerioa, Cristina R. Cardosob, Caroline Fontanaric, Maria A. Souzad, Sandra R. Afonso-Cardosod, Érika V.G. Silvac, Natalia S. Koyamab, Fernanda L. Baseia, Edson G. Soaresb, João B. Calixtoa, Sean R. Stowelle, Marcelo Dias-Baruffic,** and Lúcia H. Facciolic,*

a Universidade Federal de Santa Catarina, Campus Universitário Trindade, Centro de Ciências Biológicas, Florianópolis, SC, 88049-900, Brazil.
b Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Av. do Café s/n, Ribeirão Preto, SP,14040-903, Brazil
c Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Av. do Café s/n, Ribeirão Preto, SP,14040-903, Brazil
d Instituto de Ciências Biomédicas, Universidade Federal de Uberlândia, Av. Pará, 1720, Bloco 4C, Campus Umuarama, Uberlândia, MG, 38400-902, Brazil
e Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, 30322, USA

* Corresponding author: Tel.: ++55 16 3602 4303; fax: ++55 16 3602 4725 E-mail address: faccioli{at}fcfrp.usp.br

** Corresponding author: Tel.: ++55 16 3602 4256; fax: ++55 16 3602 4725 E-mail address: mdbaruff{at}fcfrp.usp.br

Received on May 24, 2006; revised on April 4, 2007; accepted on May 9, 2007

Extracts from the plant Synadenium carinatum latex are widely and indiscriminately used in popular medicine to treat a great number of inflammatory disorders and although the mechanisms underlying these effects remain undefined the lectin isolated from Synadenium carinatum latex (ScLL), is supposed to be in part responsible for these anti-inflammatory effects. In order to elucidate possible immunoregulatory activities of ScLL, we investigated the effects of ScLL administration in models of acute and chronic inflammation. Oral administration of ScLL significantly inhibited neutrophil and eosinophil extravasation in models of acute and chronic inflammation and reduced eosinophil and mononuclear blood counts during chronic inflammation. ScLL administration reduced IL-4 and IL-5 levels, while it increased IFN-{gamma} and IL-10 in an asthma inflammatory model, which suggested that it might induce a TH2 to TH1 shift in the adaptive immune response. ScLL also inhibited I{kappa}B{alpha} degradation, a negative regulator of pro-inflammatory NF-{kappa}B. Taken together, these results provide the first description of a single factor isolated from Synadenium carinatum latex extract with immunoregulatory functions and suggest that ScLL may be useful in the treatment of allergic inflammatory disorders.

Key words: anti-inflammatory / asthma / immune response / lectin / Synadenium carinatum


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