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Glycobiology Advance Access published online on May 4, 2007
Glycobiology, doi:10.1093/glycob/cwm049
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© The Author 2007. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Siglec-15: An immune system Siglec that is conserved throughout vertebrate evolution

Takashi Angata1, Yukako Tabuchi, Kazunori Nakamura and Mitsuru Nakamura

Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology, 1-1-1 Umezono, Tsukuba, Ibaraki 305-8568, JAPAN

1 To whom correspondence should be addressed: Phone: +81-29-861-9460; Fax: +81-29-861-3191; E-mail: takashi-angata{at}aist.go.jp

Received on February 2, 2007; revised on March 27, 2007; accepted on April 23, 2007

Siglecs are vertebrate cell-surface receptors that recognize sialylated glycans. Here we have identified and characterized a novel Siglec, named Siglec-15. Siglec-15 is a type-I transmembrane protein consisting of two immunoglobulin-like domains, a transmembrane domain containing a lysine residue, and a short cytoplasmic tail. Siglec-15 is expressed on macrophages and/or dendritic cells of human spleen and lymph nodes. We show that the extracellular domain of Siglec-15 preferentially recognizes the sialyl Tn structure. Siglec-15 associates with the activating adaptor proteins DAP12 and DAP10 via its lysine residue in the transmembrane domain, implying that it functions as an activating signaling molecule. Siglec-15 is the second human Siglec identified to have an activating signaling potential; unlike the first example Siglec-14, however, it does not have an inhibitory counterpart. Orthologs of Siglec-15 are present not only in mammals but also in other branches of vertebrates; by contrast, no other known Siglec expressed in the immune system has been conserved throughout the vertebrate evolution. Thus, Siglec-15 probably plays a conserved regulatory role in the immune system of vertebrates.

Key words: DAP12 / dendritic cells / macrophages / sialyl Tn / Siglec


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