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Glycobiology Advance Access published online on May 4, 2006
Glycobiology, doi:10.1093/glycob/cwj125
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© The Author 2006. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org
Received February 7, 2006
Revised April 27, 2006
Accepted April 27, 2006

Review Article

Glycopeptides as Versatile Tools for Glycobiology

Therese Buskas 1, Sampat Ingale 1, and Geert-Jan Boons 1 *

1 Complex Carbohydrate Research Center, University of Georgia, 315 Riverbend Road, Athens, GA, USA

* To whom correspondence should be addressed.
Geert-Jan Boons, E-mail: gjboons{at}ccrc.uga.edu


  Abstract

This review describes the recent advances in the field of glycopeptide and small glycoprotein synthesis. The strategies covered include chemical and chemo-enzymatic synthesis, native chemical ligation and expressed chemical ligation. The importance of glycopeptide synthesis is exemplified by giving the reader an overview of how versatile and important these well-defined glycopeptides are as tools in glycobiology.

Keywords: glycobiology/glycopeptides/glycoproteins/oligosaccharide/synthesis.
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