Skip Navigation



Glycobiology Advance Access published online on October 20, 2005
Glycobiology, doi:10.1093/glycob/cwj049
This Article
Right arrow Advance Access manuscript (PDF) Freely available
Right arrow Supplemental Data
Right arrow All Versions of this Article:
16/5/71R    most recent
cwj049v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Lütteke, T.
Right arrow Articles by von der Lieth, C.-W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lütteke, T.
Right arrow Articles by von der Lieth, C.-W.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2005. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org.
Received August 25, 2005
Revised October 7, 2005
Accepted October 11, 2005

Article

GLYCOCIENCES.de: An Internet Portal to Support Glycomics and Glycobiology Research

Thomas Lütteke 1, Andreas Bohne-Lang 2, Alexander Loss 3, Thomas Goetz 3, Martin Frank 4, and Claus-W. von der Lieth 3*

1 German Cancer Research Center, Spectroscopic department (B090), Molecular Modelling, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany; Present address: Massachusetts Institute of Technology, Division of Biological Engineering, 77 Massachusetts Ave., Cambridge MA 02139, USA
2 German Cancer Research Center, Spectroscopic department (B090), Molecular Modelling, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany; Present address: University of Heidelberg, Faculty for Clinical Medicine, Mannheim Medical Research Center, Theodor-Kutzer-Ufer 1-3, D-68135 Mannheim, Germany
3 German Cancer Research Center, Spectroscopic department (B090), Molecular Modelling, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany
4 German Cancer Research Center, Spectroscopic department (B090), Molecular Modelling, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany; Present address: Bijvoet Center for Biomolecular Research, Utrecht University, Padualaan 8, NL-3584 CH Utrecht, The Netherlands

* To whom correspondence should be addressed.
Claus-W. von der Lieth, E-mail: w.vonderlieth{at}dkfz.de


  Abstract

The development of glycan related databases and bioinformatics applications is considerably lagging behind compared with the wealth of available data and software tools in genomics and proteomics. Since the encoding of glycan structures is more complex, most of the bioinformatics approaches cannot be applied to glycan structures. No standard procedures exist where glycan structures found in various species, organs, tissues or cells can be routinely deposited. In this article the concepts of the GLYCOSCIENCES.de portal are described. It is demonstrated how an efficient structure based cross-linking of various glycan-related data originating from different resources can be accomplished using a single user interface. The structure oriented retrieval options - exact structure, substructure, motif, composition and sugar components - are discussed. The types of available data - references, composition, spatial structures, NMR shifts (experimental and estimated), theoretically calculated fragments and PDB entries -- are exemplified for Man3. The free availability and unrestricted use of glycan-related data is an absolute prerequisite to efficiently share distributed resources. Additionally, there is an urgent need to agree to a generally accepted exchange format as well as to a common software interface. An open access repository for glyco-related experimental data will secure that the loss of primary data will be considerably reduced.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 GlycobiologyHome page
R. Ranzinger, M. Frank, C.-W. von der Lieth, and S. Herget
Glycome-DB.org: A portal for querying across the digital world of carbohydrate sequences
Glycobiology, December 1, 2009; 19(12): 1563 - 1567.
[Abstract] [Full Text] [PDF]

Home page
 BioinformaticsHome page
M. P. Campbell, L. Royle, C. M. Radcliffe, R. A. Dwek, and P. M. Rudd
GlycoBase and autoGU: tools for HPLC-based glycan analysis
Bioinformatics, May 1, 2008; 24(9): 1214 - 1216.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
M. Frank, T. Lutteke, and C.-W. von der Lieth
GlycoMapsDB: a database of the accessible conformational space of glycosidic linkages
Nucleic Acids Res., January 12, 2007; 35(suppl_1): 287 - 290.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
P. Toukach, H. J Joshi, R. Ranzinger, Y. Knirel, and C.-W. von der Lieth
Sharing of worldwide distributed carbohydrate-related digital resources: online connection of the Bacterial Carbohydrate Structure DataBase and GLYCOSCIENCES.de
Nucleic Acids Res., January 12, 2007; 35(suppl_1): D280 - D286.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
A. Loss, R. Stenutz, E. Schwarzer, and C.-W. von der Lieth
GlyNest and CASPER: two independent approaches to estimate 1H and 13C NMR shifts of glycans available through a common web-interface.
Nucleic Acids Res., July 1, 2006; 34(suppl_2): W733 - W737.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.