Glycobiology Advance Access published online on July 21, 2005
Glycobiology, doi:10.1093/glycob/cwj016
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1 CERMAV - CNRS, (affiliated with Université Joseph Fourier), BP 53, 38041 Grenoble cedex 9, France
* To whom correspondence should be addressed. Glycosyltransferases catalyze the transfer of a sugar moiety from an activated donor sugar onto saccharide and non-saccharide acceptors. A sequence-based classification spreads glycosyltransferases in a large number of families thus reflecting the variety of molecules that can be used as acceptors. In contrast, this enzyme family is characterized by a more conserved 3D architecture. Until recently, only two different folds (GT-A and GT-B) have been identified for solved crystal structures. The recent report of a structure for a bacterial sialyltransferase allows the defination of a new fold family. Progress in the elucidation of the structures and mechanisms of glycosyltransferases are discussed in this review. To accomodate the growing number of crystal structures, the 3D-glycosyltransferase database has been created to gather structural information concerning this class of enzymes.
Received June 3, 2005
Revised July 12, 2005
Accepted July 13, 2005
Review Article
Structures and mechanisms of glycosyltransferases superfamily
2 CERMAV - CNRS, (affiliated with Université Joseph Fourier), BP 53, 38041 Grenoble cedex 9, France; NCBR, Masaryk University, Kotlarska 2, CZ-611 37 Brno, Czech Republic
3 NCBR, Masaryk University, Kotlarska 2, CZ-611 37 Brno, Czech Republic
Christelle Breton, E-mail: breton{at}cermav.cnrs.fr
Anne Imberty, E-mail: imberty{at}cermav.cnrs.fr
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