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Glycobiology Advance Access published online on December 23, 2003
Glycobiology, doi:10.1093/glycob/cwh043
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Submitted on November 12, 2003
Revised on November 30, 2003
Accepted on December 4, 2003

© 2003 Oxford University Press

ORIGINAL ARTICLES

Galectin-1 induces astrocyte differentiation, which leads to production of brain-derived neurotrophic factor

Tasuku Sasaki 1, Jun Hirabayashi 2, Hiroshi Manya 1, Ken-ichi Kasai 2, and Tamao Endo 1*

1 Glycobiology Research Group, Tokyo Metropolitan Institute of Gerontology, Foundation for Research on Aging and Promotion of Human Welfare, 35-2 Sakaecho, Itabashi-ku, Tokyo 173-0015, Japan
2 Department of Biological Chemistry, Faculty of Pharmaceutical Sciences, Teikyo University, Sagamiko, Kanagawa 199-0195, Japan

* To whom correspondence should be addressed. E-mail: endo{at}tmig.or.jp.

Abstract

Brain-derived neurotrophic factor (BDNF) is a neuroprotective polypeptide that is thought to be responsible for neuron proliferation, differentiation and survival. An agent that enhances production of BDNF is expected to be useful for the treatment of neurodegenerative diseases. Here we report that galectin-1, a member of the family of {beta}-galactoside binding proteins, induces astrocyte differentiation and strongly inhibits astrocyte proliferation, and then the differentiated astrocytes greatly enhance their production of BDNF. Induction of astrocyte differentiation and BDNF production by an endogenous mammalian lectin may be a new mechanism for preventing neuronal loss after injury.


astrocyte differentiation, brain-derived neurotrophic factor, galectin-1
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