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Glycobiology Advance Access published online on December 23, 2003
Glycobiology, doi:10.1093/glycob/cwh040
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Submitted on September 12, 2003
Accepted on November 25, 2003

© 2003 Oxford University Press

REVIEW

Biosynthesis of 6-deoxyhexose glycans in bacteria

Minna Mäki 1 and Risto Renkonen 2*

1 Rational Drug Design Program and Department of Bacteriology and Immunology, Biomedicum and Haartman Institute, P.O. Box 63, FIN-00014 University of Helsinki, Helsinki, Finland
2 Rational Drug Design Program and Department of Bacteriology and Immunology, Biomedicum and Haartman Institute, P.O. Box 63, FIN-00014 University of Helsinki, Helsinki, Finland; HUCH Laboratory Diagnostics, Helsinki University Central Hospital, P.O. Box 401, FIN-00029 HUCH, Helsinki, Finland

* To whom correspondence should be addressed. E-mail: Risto.Renkonen{at}Helsinki.Fi.

Abstract

After the breakthroughs in the genomic sequencing one of the next challenges remains to understand the molecular biology of other classes of biomolecules, such as protein and lipids, many of which carry specific glycomodification when mediating their biological functions. This review focuses on the 6-deoxyhexose biosynthesis of cell surface glycans of three Gram-negative pathogens Helicobacter pylori, Pseudomonas aeruginosa, and Actinobacillus actinomycetemcomitans serotype a. 6-deoxysugars are important functional components of cell surface glycans and their biosynthetic pathways might be suitable targets for novel interventions of antibacterial chemotherapy.


fucose, rhamnose, 6-deoxy-talose, nucleotide sugars
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