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Glycobiology Advance Access published online on September 9, 2003
Glycobiology, doi:10.1093/glycob/cwg113
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Submitted on July 9, 2003
Accepted on August 14, 2003

© 2003 Oxford University Press

ORIGINAL ARTICLES

A new superfamily of protein-O-fucosyltransferases, {alpha}2-fucosyltransferases, and {alpha}6-fucosyltransferases: phylogeny and identification of conserved peptide motifs

Ivan Martinez-Duncker 1, Rosella Mollicone 1, Jean-Jacques Candelier 1, Christelle Breton 2, and Rafael Oriol 1*

1 Unité de Glycobiologie et Signalisation Cellulaire, INSERM U504, GDR CNRS 2590, Université de Paris Sud XI, 16 Ave Paul Vaillant-Couturier, 94807 Villejuif Cedex, France
2 CERMAV-CNRS, BP 53, 38041 Grenoble Cedex 9, France

* To whom correspondence should be addressed. E-mail: oriol{at}vjf.inserm.fr..

Abstract

The presence of three conserved peptide motifs shared by {alpha}2-fucosyltransferases, {alpha}6-fucosyltransferases, the protein-O-fucosyltransferase family 1 (POFUT1) and a newly identified protein-O-fucosyltransferase family 2 (POFUT2), together with evidence that the present genes encoding for these enzymes have originated from a common ancestor by duplication and divergent evolution, suggests that they constitute a new superfamily of fucosyltransferases.


{alpha}2-fucosyltransferase, {alpha}6-fucosyltransferase, conserved peptide motifs, phylogeny, protein-O-fucosyltransferase
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