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Glycobiology Advance Access published online on May 7, 2003
Glycobiology, doi:10.1093/glycob/cwg075
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Accepted on April 24, 2003

© 2003 Oxford University Press

REVIEW

The contribution of N-glycans and their processing in the endoplasmic reticulum to glycoprotein biosynthesis

E. Sergio Trombetta 1*

1 Department of Cell Biology, Yale University School of Medicine, 333 Cedar Street, PO Box 208002, New Haven, Connecticut 06520

* To whom correspondence should be addressed. E-mail: sergio.trombetta{at}yale.edu.

Abstract

The attachment of N-glycans to nascent glycoproteins in the endoplasmic reticulum (ER) is intimately related to glycoprotein biogenesis. Processing of N-linked oligosaccharides begins in the ER and participates in glycoprotein folding and assembly. The elucidation of N-glycan processing mechanisms in the ER is uncovering their role in glycoprotein biosynthesis.


glycoprotein, processing, folding, transport, degradation
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