Glycobiology Advance Access published online on March 19, 2003
Glycobiology, doi:10.1093/glycob/cwg054
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
© 2003 Oxford University Press
REVIEW
1 Graduate Program in Cellular and Molecular Biology, University of Michigan Medical School, Ann Arbor, MI 48109 Fucose is a deoxyhexose that is present in a wide variety of organisms. In mammals, fucose-containing glycans have important roles in blood transfusion reactions, selectin-mediated leukocyte-endothelial adhesion, host-microbe interactions, and numerous ontogenic events including signaling events by the Notch receptor family. Alterations in the expression of fucosylated oligosaccharides have also been observed in several pathological processes, including cancer and atherosclerosis. Fucose deficiency is accompanied by a complex set of phenotypes both in humans with leukocyte adhesion deficiency type II (LAD II; also known as Congenital Disorder of Glycosylation type IIc, or CDG-IIc) and in a recently generated strain of mice with a conditional defect in fucosylated glycan expression. Fucosylated glycans are constructed by fucosyltransferases, which require the substrate GDP-fucose. Two pathways for the synthesis of GDP-fucose operate in mammalian cells, the GDP-mannose-dependent de novo pathway and the free fucose-dependent salvage pathway. In this review, we focus on the biological functions of mammalian fucosylated glycans and the biosynthetic processes leading to formation of the fucosylated glycan precursor GDP-fucose.
Fucose: biosynthesis and biological function in mammals
2 Graduate Program in Cellular and Molecular Biology, University of Michigan Medical School, Ann Arbor, MI 48109; Howard Hughes Medical Institute, University of Michigan Medical School, Ann Arbor, MI 48109; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  W.-W. Chang, C. H. Lee, P. Lee, J. Lin, C.-W. Hsu, J.-T. Hung, J.-J. Lin, J.-C. Yu, L.-e. Shao, J. Yu, et al. Expression of Globo H and SSEA3 in breast cancer stem cells and the involvement of fucosyl transferases 1 and 2 in Globo H synthesis PNAS, August 19, 2008; 105(33): 11667 - 11672. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Zhou, L. W. Li, Q. Yan, B. Petryniak, Y. Man, C. Su, J. Shim, S. Chervin, and J. B. Lowe Notch-dependent control of myelopoiesis is regulated by fucosylation Blood, July 15, 2008; 112(2): 308 - 319. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Dissing-Olesen, M. Thaysen-Andersen, M. Meldgaard, P. Hojrup, and B. Finsen The Function of the Human Interferon-{beta}1a Glycan Determined in Vivo J. Pharmacol. Exp. Ther., July 1, 2008; 326(1): 338 - 347. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Meng, D. S. Newburg, C. Young, A. Baker, S. L. Tonkonogy, R. B. Sartor, W. A. Walker, and N. N. Nanthakumar Bacterial symbionts induce a FUT2-dependent fucosylated niche on colonic epithelium via ERK and JNK signaling Am J Physiol Gastrointest Liver Physiol, October 1, 2007; 293(4): G780 - G787. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. C. Turnock, L. Izquierdo, and M. A. J. Ferguson The de Novo Synthesis of GDP-fucose Is Essential for Flagellar Adhesion and Cell Growth in Trypanosoma brucei J. Biol. Chem., September 28, 2007; 282(39): 28853 - 28863. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Park, K.-S. Ryu, D. Choi, J. Kwak, and C. Park Characterization and role of fucose mutarotase in mammalian cells Glycobiology, September 1, 2007; 17(9): 955 - 962. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Shetterly, F. Jost, S. R. Watson, R. Knegtel, B. A. Macher, and E. H. Holmes Site-specific Fucosylation of Sialylated Polylactosamines by {alpha}1,3/4-Fucosyltransferases-V and -VI Is Defined by Amino Acids Near the N Terminus of the Catalytic Domain J. Biol. Chem., August 24, 2007; 282(34): 24882 - 24892. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Ihara, Y. Ikeda, S. Toma, X. Wang, T. Suzuki, J. Gu, E. Miyoshi, T. Tsukihara, K. Honke, A. Matsumoto, et al. Crystal structure of mammalian {alpha}1,6-fucosyltransferase, FUT8 Glycobiology, May 1, 2007; 17(5): 455 - 466. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Nystrom, A. Grahn, M. Lindh, M. Brytting, U. Mandel, G. Larson, and S. Olofsson Virus-induced transcriptional activation of host FUT genes associated with neo-expression of Ley in cytomegalovirus-infected and sialyl-Lex in varicella-zoster virus-infected diploid human cells Glycobiology, April 1, 2007; 17(4): 355 - 366. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T.-L. Hsu, S. R. Hanson, K. Kishikawa, S.-K. Wang, M. Sawa, and C.-H. Wong Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells PNAS, February 20, 2007; 104(8): 2614 - 2619. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Ma, J. L. Simala-Grant, and D. E. Taylor Fucosylation in prokaryotes and eukaryotes Glycobiology, December 1, 2006; 16(12): 158R - 184R. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Sawa, T.-L. Hsu, T. Itoh, M. Sugiyama, S. R. Hanson, P. K. Vogt, and C.-H. Wong Glycoproteomic probes for fluorescent imaging of fucosylated glycans in vivo PNAS, August 15, 2006; 103(33): 12371 - 12376. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Luo, K. Koles, W. Vorndam, R. S. Haltiwanger, and V. M. Panin Protein O-Fucosyltransferase 2 Adds O-Fucose to Thrombospondin Type 1 Repeats J. Biol. Chem., April 7, 2006; 281(14): 9393 - 9399. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. M. Comelli, S. R. Head, T. Gilmartin, T. Whisenant, S. M. Haslam, S. J. North, N.-K. Wong, T. Kudo, H. Narimatsu, J. D. Esko, et al. A focused microarray approach to functional glycomics: transcriptional regulation of the glycome Glycobiology, February 1, 2006; 16(2): 117 - 131. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Sturiale, R. Barone, A. Fiumara, M. Perez, M. Zaffanello, G. Sorge, L. Pavone, S. Tortorelli, J. F. O'Brien, J. Jaeken, et al. Hypoglycosylation with increased fucosylation and branching of serum transferrin N-glycans in untreated galactosemia Glycobiology, December 1, 2005; 15(12): 1268 - 1276. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. K. Toppila-Salmi, J. P. Myller, T. V. M. Torkkeli, J. V. Muhonen, J. A. Renkonen, M. E. Rautiainen, and R. L. O. Renkonen Endothelial L-Selectin Ligands in Sinus Mucosa during Chronic Maxillary Rhinosinusitis Am. J. Respir. Crit. Care Med., June 15, 2005; 171(12): 1350 - 1357. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Luo and R. S. Haltiwanger O-Fucosylation of Notch Occurs in the Endoplasmic Reticulum J. Biol. Chem., March 25, 2005; 280(12): 11289 - 11294. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Coyne, B. Reinap, M. M. Lee, and L. E. Comstock Human Symbionts Use a Host-Like Pathway for Surface Fucosylation Science, March 18, 2005; 307(5716): 1778 - 1781. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Okajima, A. Xu, L. Lei, and K. D. Irvine Chaperone Activity of Protein O-Fucosyltransferase 1 Promotes Notch Receptor Folding Science, March 11, 2005; 307(5715): 1599 - 1603. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Huopaniemi, M. Kolmer, J. Niittymaki, M. Pelto-Huikko, and R. Renkonen Inflammation-induced transcriptional regulation of Golgi transporters required for the synthesis of sulfo sLex glycan epitopes Glycobiology, December 1, 2004; 14(12): 1285 - 1294. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. K. Patnaik, B. Potvin, and P. Stanley LEC12 and LEC29 Gain-of-Function Chinese Hamster Ovary Mutants Reveal Mechanisms for Regulating VIM-2 Antigen Synthesis and E-selectin Binding J. Biol. Chem., November 26, 2004; 279(48): 49716 - 49726. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. K. van de Wetering, A. van Remoortere, A. B. Vaandrager, J. J. Batenburg, L. M. G. van Golde, C. H. Hokke, and J. J. van Hellemond Surfactant Protein D Binding to Terminal {alpha}1-3-Linked Fucose Residues and to Schistosoma mansoni Am. J. Respir. Cell Mol. Biol., November 1, 2004; 31(5): 565 - 572. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.-S. Ryu, C. Kim, I. Kim, S. Yoo, B.-S. Choi, and C. Park NMR Application Probes a Novel and Ubiquitous Family of Enzymes That Alter Monosaccharide Configuration J. Biol. Chem., June 11, 2004; 279(24): 25544 - 25548. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Sulzenbacher, C. Bignon, T. Nishimura, C. A. Tarling, S. G. Withers, B. Henrissat, and Y. Bourne Crystal Structure of Thermotoga maritima {alpha}-L-Fucosidase: INSIGHTS INTO THE CATALYTIC MECHANISM AND THE MOLECULAR BASIS FOR FUCOSIDOSIS J. Biol. Chem., March 26, 2004; 279(13): 13119 - 13128. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. E. Domino and E. A. Hurd LacZ expression in Fut2-LacZ reporter mice reveals estrogen-regulated endocervical glandular expression during estrous cycle, hormone replacement, and pregnancy Glycobiology, February 1, 2004; 14(2): 169 - 175. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Martinez-Duncker, J.-C. Michalski, C. Bauvy, J.-J. Candelier, B. Mennesson, P. Codogno, R. Oriol, and R. Mollicone Activity and tissue distribution of splice variants of {alpha}6-fucosyltransferase in human embryogenesis Glycobiology, January 1, 2004; 14(1): 13 - 25. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Martinez-Duncker, R. Mollicone, J.-J. Candelier, C. Breton, and R. Oriol A new superfamily of protein-O-fucosyltransferases, {alpha}2-fucosyltransferases, and {alpha}6-fucosyltransferases: phylogeny and identification of conserved peptide motifs Glycobiology, December 1, 2003; 13(12): 1C - 5C. [Abstract] [Full Text] [PDF]
|
|