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Glycobiology vol 3 no 2 pp. 131-136, 1993
© 1993

research-article

The vascular E-selectin binds to the leukocyte integrins CD11/CD18

Pekka Kotovuori1, Eveliina Tontti1, Rod Pigott2, Maura Shepherd2, Makoto Kiso3, Akira Hasegawa3, Risto Renkonen4, Pekka Nortamo1, Dario C. Altieri5 and Carl G. Gahmberg1,6

1Department of Biochemistry, University of Helsinki Unioninkatu 35, SF-00170 Helsinki, Finland
2British Bio-Technology Ltd Oxford, UK
3Department of Applied Bioorganic Chemistry, Gifu University Gifu, Japan
4Department of Bacteriology and Immunology, University of Helsinki Helsinki, Finland
5Scripps Research Institute, La Jolla CA, USA

6To whom correspondence should be addressed

Received on November 6, 1992; accepted on December 7, 1992

Leukocyte adhesion involves at least three molecular families of adhesion proteins: the leukocyte integrins CD11/CD18, the intercellular adhesion molecules (ICAMs) and the carbohydrate-binding L-, E- and P-selectins. The intercellular adhesion molecules are well-known ligands for the CD11/CD18 integrins. We now show that E-selectin specifically binds to the sialyl Lex carbohydrate epitopes of leukocyte integrins. Thus, the different families of leukocyte adhesion molecules form an integrated adhesion network.

adhesion integrins leukocyte selectin


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