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Glycobiology vol 2 no 4 pp. 337-343, 1992
© 1992

research-article

Developmental sialic acid modifications in rat organs

Elaine A. Muchmore

Hematology-Oncology Division, Department of Medicine, University of California at San Diego VA Medical Center, 3350 La Jolla Village Drive. San Diego, CA 92161, USA

Received on March 20, 1992; accepted on May 17, 1992

The changes in expression of sialic acids in Sprague-Dawley rats in the prenatal and early postnatal time period have been examined in multiple organs, both visceral and non-visceral. In all organs examined, there is a dramatic increase in both N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc) shortly after birth. The bulk of the sialic acid is present in the ganglioside fraction in all tissues examined. As total amounts of sialic acid present in gangliosides decrease, the proportion present in the low molecular weight cytosolic fraction increases. A curious observation is that Neu5Ac hydroxylase activity is present at the time of the increase in sialic acid, but its activity does not correlate with Neu5Gc expression after the early postnatal period. This implies that Neu5Gc expression has another level of regulation besides CMP-Neu5Ac hydroxylase activity.

N-acetylneuraminic acid N-glycolylneuraminic acid sialic acids


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