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Glycobiology Advance Access originally published online on March 14, 2009
Glycobiology 2009 19(6):568-575; doi:10.1093/glycob/cwp032
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© The Author 2009. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Review

Recognition of non-self-polysaccharides by C-type lectin receptors dectin-1 and dectin-2

S Tyler Hollmig, Kiyoshi Ariizumi and Ponciano D Cruz, Jr1

Department of Dermatology, University of Texas Southwestern Medical Center, and Section of Dermatology (Medical Services), Dallas Veterans Affairs Medical Center, Dallas, TX, USA

1 To whom correspondence should be addressed: e-mail: ponciano.cruz{at}utsouthwestern.edu, susan.milberger{at}utsouthwestern.edu

Received on December 12, 2008; revised on February 24, 2009; accepted on February 24, 2009

The discovery of several transmembrane receptors expressed by antigen presenting cells, including those that detect and interact with specific sugar moieties on the surface of microbes, has improved our understanding of how immunity against infection is generated. This knowledge, in turn, prompted us to review such interactions with emphasis on C-type lectin receptors and a focus on the roles of dectin-1 and dectin-2 in anti-fungal immunity.


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