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Glycobiology Advance Access originally published online on July 11, 2008
Glycobiology 2008 18(10):747-749; doi:10.1093/glycob/cwn065
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© The Author 2008. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Working group report: the roles of glycans in hemostasis, inflammation and vascular biology

Ajit P Varki1,4, Linda G Baum2,5, Susan L Bellis2,6, Richard D Cummings7, Jeffrey D Esko8, Gerald W Hart9, Robert J Linhardt10, John B Lowe11, Rodger P McEver12, Arun Srivastava13 and Rita Sarkar3,14

4 Departments of Medicine and Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093
5 Department of Pathology, University of California, Los Angeles, CA 90024
6 Department of Physiology and Biophysics, University of Alabama, Birmingham, AL 35294
7 Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322
8 Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093
9 Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205
10 Department of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, Troy, NY 12180
11 Department of Pathology, Case Western Reserve University, Cleveland, OH 44106
12 Cardiovascular Biology Program, Oklahoma Medical Research Foundation (OMRF), Oklahoma City, OK 73104
13 Division of Cellular and Molecular Therapy, Departments of Pediatrics, Molecular Genetics and Microbiology, and Powell Gene Therapy Center, University of Florida College of Medicine, Gainesville, FL 32610
14 National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA

1 To whom correspondence should be addressed: Tel: +1-858-534-2214; Fax: +1-858-534-5611; e-mail: a1varki@ucsd.edu

The first 150 words of the full text of this article appear below.

Context

The first major collaborative effort on glycomics funded by the US National Institutes of Health was the Consortium for Functional Glycomics, begun in 2001. The focus of the consortium, which was funded by the National Institute of General Medical Science (NIGMS), includes cataloging structures of glycans in selected cell types and organs using mass spectrometry, creating and characterizing the phenotypes of mice engineered with deficiencies in glyco-related genes, and creating specialized microarrays to study gene expression and glycan binding specificity. New approaches will be needed to capitalize on this and other emerging glycomics knowledge to develop new diagnostics and treatments. With this in mind, the Division of Blood Diseases and resources of the National Heart, Lung, and Blood Institute (NHLBI) convened a working group of scientific investigators on February 25–26, 2008, in Bethesda, MD, to identify scientific opportunities and priorities emerging from the recent explosion of technological and biological advances . . . [Full Text of this Article]

Preamble

Rationale

Research opportunities and priorities

Existing challenges


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