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Glycobiology Advance Access originally published online on April 2, 2003
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Glycobiology, 2003, Vol. 13, No. 11 743-747
© 2003 Oxford University Press

Structural differences between the alkali-extracted water-soluble cell wall polysaccharides from mycelial and yeast phases of the pathogenic dimorphic fungus Paracoccidioides brasiliensis

Oussama Ahrazem2, Alicia Prieto2, Gioconda San-Blas3, Juan Antonio Leal2, Jesús Jiménez-Barbero2 and Manuel Bernabé1,4

2 Centro de Investigaciones Biológicas, CSIC, Velázquez 144, 28006-Madrid, Spain; 3 Centro de Microbiología y Biología Celular, IVIC, P.O. Box 21827, Caracas 1020A, Venezuela; and 4 Instituto de Química Orgánica, CSIC, Juan de la Cierva 3, 28006-Madrid, Spain

Received on January 13, 2003; revised on March 13, 2003; accepted on March 13, 2003

Paracoccidioides brasiliensis is a pathogenic dimorphic fungus causing paracoccidioidomycosis, the most widespread systemic mycosis in Latin America. We have studied the structure of the alkali-extracted water-soluble cell wall polysaccharides (F1SS) from both mycelial and yeast phases of this fungus by using chemical analysis and NMR spectroscopic techniques. The F1SS polysaccharide from the mycelial phase consists of a trisaccharidic repeating unit of ->6)-[{alpha}-Galf -(1->6)-{alpha}-Manp-(1->2)]-{alpha}-Manp-(1->. The F1SS polysaccharide of the yeast phase maintains 10% of the structure of the mycelium phase, but the main structure contain a disaccharide repeating unit of ->6)-[-{alpha}-Manp-(1->2)]-{alpha}-Manp-(1->, alternating with a trisaccharide repeating block of ->6)-[ß-Galf -(1->6)-{alpha}-Manp-(1->2)]-{alpha}-Manp-(1->.

1 To whom correspondence should be addressed; e-mail: mbernabe{at}iqog.csic.es


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