Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (17)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Monteiro, M. A.
Right arrow Articles by Perry, M. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Monteiro, M. A.
Right arrow Articles by Perry, M. B.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Glycobiology, 2000, Vol. 10, No. 7 701-713
© 2000 Oxford University Press

Expression of histo-blood group antigens by lipopolysaccharides of Helicobacter pylori strains from Asian hosts: the propensity to express type 1 blood-group antigens

Mario A. Monteiro1, Peng-yuan Zheng2, Bow Ho2, Shin-ichi Yokota3, Ken-ichi Amano3, Zhi-jun Pan4, Douglas E. Berg4, Kenneth H. Chan, Leann L. MacLean and Malcolm B. Perry

Institute for Biological Sciences, National Research Council, Ottawa, Ontario, Canada, 2Department of Microbiology, National University of Singapore, Singapore, 3Central Research Laboratory, Akita University School of Medicine, Akita, Japan, and 4Departments of Molecular Microbiology and Genetics, Washington University School of Medicine, St. Louis, MO 63130, USA

Past studies have shown that the cell surface lipopolysaccharides (LPSs) of the ubiquitous human gastric pathogen Helicobacter pylori (a type 1 carcinogen) isolated from people residing in Europe and North America express predominantly type 2 Lewis x (Lex) and Ley epitopes and, infrequently, type 1 Lea, Leb, and Led antigens. This production of Lewis blood-group structures by H. pylori LPSs, similar to those found in the surfaces of human gastric cells, allows the bacterium to mimic its human niche. In this study, LPSs of H.pylori strains extracted from patients living in China, Japan, and Singapore were chemically and serologically analyzed. When compared with Western H.pylori LPSs, these Asian strains showed a stronger tendency to produce type 1 blood groups. Of particular interest, and novel observations in H.pylori, the O-chain regions of strains F-58C and R-58A carried type 1 Lea without the presence of type 2 Lex, strains R-7A and H607 were shown to have the capability of producing the type 1 blood group A antigen, and strains CA2, H507, and H428 expressed simultaneously the difucosyl isomeric antigens, type 1 Leb and type 2 Ley. The apparent proclivity for the production of type 1 histo-blood group antigens in Asian H.pylori LPSs, as compared with Western strains, may be an adaptive evolutionary effect in that differences in the gastric cell surfaces of the respective hosts might be significantly dissimilar to select for the formation of different LPS structures on the resident H.pylori strain.

1 To whom correspondence should be addressed at: Institute for Biological Sciences, National Research Council, 100 Sussex Drive, Ottawa, Ontario, K1A 0R6, Canada


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J Med MicrobiolHome page
B.-S. Sheu and J.-J. Wu
Type 1 and 2 Lewis antigens of Helicobacter pylori - a potential marker of the human geographical distribution
J. Med. Microbiol., May 1, 2008; 57(5): 543 - 544.
[Full Text] [PDF]

Home page
 J Med MicrobiolHome page
E. Altman, H. Fernandez, V. Chandan, B. A. Harrison, M. W. Schuster, L. O. Rademacher, and C. Toledo
Analysis of Helicobacter pylori isolates from Chile: occurrence of selective type 1 Lewis b antigen expression in lipopolysaccharide
J. Med. Microbiol., May 1, 2008; 57(5): 585 - 591.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
M. P. Bergman, A. Engering, H. H. Smits, S. J. van Vliet, A. A. van Bodegraven, H.-P. Wirth, M. L. Kapsenberg, C. M.J.E. Vandenbroucke-Grauls, Y. van Kooyk, and B. J. Appelmelk
Helicobacter pylori Modulates the T Helper Cell 1/T Helper Cell 2 Balance through Phase-variable Interaction between Lipopolysaccharide and DC-SIGN
J. Exp. Med., October 18, 2004; 200(8): 979 - 990.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. P. Moran, Y. A. Knirel, S.'y. N. Senchenkova, G. Widmalm, S. O. Hynes, and P.-E. Jansson
Phenotypic Variation in Molecular Mimicry between Helicobacter pylori Lipopolysaccharides and Human Gastric Epithelial Cell Surface Glycoforms. ACID-INDUCED PHASE VARIATION IN LEWISX AND LEWISY EXPRESSION BY H. PYLORI LIPOPOLYSACCHARIDES
J. Biol. Chem., February 15, 2002; 277(8): 5785 - 5795.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Microbiol.Home page
S. O. Hynes, N. Broutet, Eurohepygast Study Group, T. Wadstrom, M. Mikelsaar, P. W. O'Toole, J. Telford, L. Engstrand, S. Kamiya, A. F. Mentis, et al.
Phenotypic Variation of Helicobacter pylori Isolates from Geographically Distinct Regions Detected by Lectin Typing
J. Clin. Microbiol., January 1, 2002; 40(1): 227 - 232.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.