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Glycobiology, 1999, Vol. 9, No. 12 1357-1369
© 1999 Oxford University Press

C-Type lectin-like domains in Caenorhabditis elegans: predictions from the complete genomesequence

Kurt Drickamera and Roger B.Dodd

Glycobiology Institute, Department of Biochemistry, Universityof Oxford, Oxford OX1 3QU, UK

Protein modules related to the C-type carbohydrate-recognitiondomains of animal lectins are found in at least 125 proteinsencoded in the Caenorhabditis elegans genome. Withinthese proteins, 183 C-type lectin-like domains (CTLDs) have beenidentified. The proteins have been classified based on the overallarrangement of modules within the polypeptides and based on sequence similaritybetween the CTLDs. The C.elegans proteins generallyhave different domain organization from known mammalian proteinscontaining CTLDs. Most of the CTLDs are divergent in sequence fromthose in mammalian proteins. However, 19 show conservationof most of the amino acid residues that ligate Ca2+ toform a carbo­hydrate-binding site in vertebrate C-typecarbohydrate-recognition domains. Seven of these domains are particularly similarin sequence to mannose- and N-acetylglucosamine-binding domainsin the vicinity of this Ca2+ site.

a Towhom correspondence should be addressed at: Department of Biochemistry, Universityof Oxford, South Parks Road, Oxford OX1 3QU, United Kingdom


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