Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (21)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Bennett, E. P.
Right arrow Articles by Clausen, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bennett, E. P.
Right arrow Articles by Clausen, H.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Glycobiology, Vol 8, 547-555, Copyright © 1998 by Society for Glycobiology

ORIGINAL ARTICLES

Genomic organization and chromosomal localization of three members of the UDP-N-acetylgalactosamine: polypeptide N- acetylgalactosaminyltransferase family

EP Bennett, DO Weghuis, G Merkx, AG van Kessel, H Eiberg and H Clausen
Faculty of Health Sciences, School of Dentistry, University of Copenhagen, Copenhagen, Denmark.

A homologous family of UDP- N -acetylgalactosamine: polypeptide N - acetylgalactosaminyltransferases (GalNAc-transferases) initiate O- glycosylation. These transferases share overall amino acid sequence similarities of approximately 45-50%, but segments with higher similarities of approximately 80% are found in the putative catalytic domain. Here we have characterized the genomic organization of the coding regions of three GalNAc-transferase genes and determined their chromosomal localization. The coding regions of GALNT1 , -T2 , and -T3 were found to span 11, 16, and 10 exons, respectively. Several intron/exon boundaries were conserved within the three genes. One conserved boundary was shared in a homologous C. elegans GalNAc- transferase gene. Fluorescence in situ hybridization showed that GALNT1 , -T2 , and -T3 are localized at chromosomes 18q12-q21, 1q41-q42, and 2q24-q31, respectively. These results suggest that the members of the polypeptide GalNAc-transferase family diverged early in evolution from a common ancestral gene through gene duplication.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 IOVSHome page
P. Argueso, A. Tisdale, U. Mandel, E. Letko, C. S. Foster, and I. K. Gipson
The Cell-Layer- and Cell-Type-Specific Distribution of GalNAc-Transferases in the Ocular Surface Epithelia Is Altered during Keratinization
Invest. Ophthalmol. Vis. Sci., January 1, 2003; 44(1): 86 - 92.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
N. Kociok, A. Hueber, P. Esser, U. Schraermeyer, G. Thumann, T. T. Luther, J. Jordan, G. Welsandt, and B. Kirchhof
Vitreous Treatment of Cultured Human RPE Cells Results in Differential Expression of 10 New Genes
Invest. Ophthalmol. Vis. Sci., July 1, 2002; 43(7): 2474 - 2480.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Schwientek, E. P. Bennett, C. Flores, J. Thacker, M. Hollmann, C. A. Reis, J. Behrens, U. Mandel, B. Keck, M. A. Schafer, et al.
Functional Conservation of Subfamilies of Putative UDP-N-acetylgalactosamine:Polypeptide N-Acetylgalactosaminyltransferases in Drosophila, Caenorhabditis elegans, and Mammals. ONE SUBFAMILY COMPOSED OF l(2)35Aa IS ESSENTIAL IN DROSOPHILA
J. Biol. Chem., June 14, 2002; 277(25): 22623 - 22638.
[Abstract] [Full Text] [PDF]

Home page
 GlycobiologyHome page
A. E. Manzi, K. Norgard-Sumnicht, S. Argade, J. D. Marth, H. van Halbeek, and A. Varki
Exploring the glycan repertoire of genetically modified mice by isolation and profiling of the major glycan classes and nano-NMR analysis of glycan mixtures
Glycobiology, July 1, 2000; 10(7): 669 - 689.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Schwientek, M. Nomoto, S. B. Levery, G. Merkx, A. G. van Kessel, E. P. Bennett, M. A. Hollingsworth, and H. Clausen
Control of O-Glycan Branch Formation. MOLECULAR CLONING OF HUMAN cDNA ENCODING A NOVEL beta 1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE FORMING CORE 2 AND CORE 4
J. Biol. Chem., February 19, 1999; 274(8): 4504 - 4512.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
E. P. Bennett, H. Hassan, U. Mandel, E. Mirgorodskaya, P. Roepstorff, J. Burchell, J. Taylor-Papadimitriou, M. A. Hollingsworth, G. Merkx, A. G. van Kessel, et al.
Cloning of a Human UDP-N-Acetyl-alpha -D-Galactosamine:Polypeptide N-Acetylgalactosaminyltransferase That Complements Other GalNAc-Transferases in Complete O-Glycosylation of the MUC1 Tandem Repeat
J. Biol. Chem., November 13, 1998; 273(46): 30472 - 30481.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.