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Glycobiology vol 7 no 5 pp. 605-615, 1997
© 1997

research-article

Developmental changes in carbohydrate antigens in embryonic rat lens

Manabu Ogiso4, Nobuyuki Saito1,2, Motonori Hoshi3 and Michiji Komoto2

Cell and Information, PRESTO, Japan Science and Technology Corporation (JST), Japan
1Eye Clinic, Okura National Hospital Tokyo 157, Japan
2Department of Ophthalmology, Toho University School of Medicine Tokyo 143, Japan
3Department of Life Science, Faculty of Bioscience and Biotechnology. Tokyo Institute of Technology Yokohama 226, Japan

4To whom correspondence should be addressed at 8–9–303 Higashimaita-machi, Minami-ku, Yokohama 232, Japan

The functions of glycosphingolipids, especially those containing the {alpha}-galactosyl epitope, were investigated during the development and differentiation of rat lens. Glycosphingolipids in embryonic lens tissue were mainly composed of neolacto-series glycosphingolipids and sialic acid-containing ganglio-series gangliosides GM3 and GD3. These glycosphingolipids and gangliosides were widely expressed on cell membranes in the lens vesicle and the elongating lens fibers. In particular, the expression of neolacto-series glycosphingolipids with the {alpha}-galactosyl epitope was found to be associated with the differentiation and interaction of lens fibers. Glycoproteins with the {alpha}-galactosyl epitope was also involved in the elongation of lens fibers. The expression of the glycoproteins was highly specific in elongating lens fibers when these were examined in head sections obtained at various embryonic stages. Thus, the {alpha}-galactosyl epitope on glycosphingolipids and glycoproteins appears to be associated with the differentiation and elongation of lens fibers in the rat Evolution-related changes in the expression of carbohydrate antigens are also discussed in relation to the development and cell-to-cell interaction of lens fibers in mammals.

ganglioside glycosphingolipid immunohistochemistry lens


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