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Glycobiology vol 5 no 5 pp. 525-534, 1995
© 1995

research-article

Sialylation of intestinal microvillar membranes in newborn, sucking and weaned pigs

Timothy P. King, Robert Begbie, Diane Slater, Morag McFadyen, Amanda Thom and Denise Kelly

Rowett Research Institute Bucksbum, Aberdeen, AB2 9SB, UK

Received on March 8, 1995; accepted on April 18, 1995

Affinity cytochemistry and biochemistry revealed distinctive temporal changes in the expression of sialylated and compositionally related membrane glycoconjugates in the pig small intestine between birth and weaning. The expression of membrane NeuAc{alpha}2,6 moieties, recognized by Sambucus nigra agglutinin-1, was high in newborn pigs, declined slightly during sucking and was very low in weaned animals. Conversely, the expression of membrane NeuAc{alpha}2r3 moieties, recognized by Maackia amurensis agglutinin-2, was low at birth but higher in sucking and weaned animals. Histoblood group O- and A-antigen expression was first detected in a minority of sucking pigs, but was evident in all weaned pigs examined. Lactase glycoforms were isolated from solubilized microvillar membranes of newborn and weaned pigs. The newborn (predominantly {alpha}2,6-sialylated) and weaned (predominantly {alpha}1,2-fucosylated) glycoforms exhibited similar specific activity, indicating that postnatal lactase decline in the pig intestine is unrelated to temporal changes in membrane sialylation and fucosylation.

fucosylation lactase lectins intestine sialylation


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