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Glycobiology vol 3 no 2 pp. 179-184, 1993
© 1993

research-article

S-type lectins occur also in invertebrates: High conservation of the carbohydrate recognition domain in the lectin genes from the marine sponge Geodia cydonium

Karin Pfeifer, Martina Haasemann1, Vera Gamulin2, Hagen Bretting3, Falk Fahrenholz4 and Werner E.G. Müller5

Institut für Physiologische Chemie, Universität Duesbergweg 6, D-6500 Mainz
1MIPS, Max-Planck-Institut für Biochemie D-8033 Martinsried, FRG
2Institute Ruder Boskovic, Center for Organic Chemistry and Biochemistry 41001 Zagreb, Croatia
3Zoologisches Institut, Universität D-2000 Hamburg
4Max-Planck-Institut füur Biophysik D-6000 Frankfurt, FRG

5Author to whom correspondence should be addressed

Received on November 20, 1992; accepted on January 1, 1993

The marine sponge Geodia cydonium contains several lectins. The main component, called lectin-1, is composed of three to four identical subunits. The subunits of the lectins were cloned from a cDNA library; two clones were obtained. From the deduced aa sequence of one clone, LECT-1, a mol. wt of 15 313 Da is calculated; this value is in good agreement with mass spectrometric analysis of 15 453 ± 25 Da. The sequence of another clone, LECT-2, was analysed and the aa sequence was deduced (15 433 Da). The two subunits have a framework sequence of 38 conserved aa which are characteristic for the carbohydrate-binding site of vertebrate S-type lectins. Clustering of lectin sequences of various species following their pairwise comparison establishes a dendrogram, which reveals that the sponge lectin could be considered as the ancestor for vertebrate S-type lectins.

Geodia cydonium lectin sponges S-type lectin


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