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Glycobiology vol 2 no 6 pp. 523-528, 1992
© 1992

review-article

Heparan sulphate in the binding and activation of basic fibroblast growth factor

J.T. Gallagher and J.E. Turnbull

Departments of Medical Oncology and Clinical Research, Christie Hospital NHS Trust Wilmslow Road, Manchester, M20 9BX, UK

Received on September 18, 1992; accepted on September 21, 1992

Heparan sulphate proteoglycans (HSPGs) are widely distributed in animal tissues, but their most prominent locations are cell surface membranes and basement membranes. Their influence on various fundamental aspects of cell behaviour (e.g. cell adhesion, growth and morphogenesis) are dependent on the specific binding properties of the heparan sulphate (HS) chains. These polysaccharides are complex structures in which N-sulphated glucosamine and ester sulphate groups tend to be clustered in discrete regions of the chain separated by sequences enriched in N-acetylglucosamine residues, but with a low sulphate concentration. The sulphated domains contain the sugar residue sequences for interaction with specific proteins essential for HS function. In this review, we describe the plasma membrane HSPGs and their role in regulating the activity of basic fibroblast growth factor (bFGF).

cell surfaces fibroblast growth factor (FGF) heparan sulphate proteoglycans syndecan


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