| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Glycobiology vol 2 no 4 pp. 271-277, 1992
© 1992
review-article |
Mammalian glycosyltransferases: genomic organization and protein structure
Department of Medical Chemistry, Vrije Universiteit Van der Boechorststraat 7, NL-1081 BT Amsterdam, The Netherlands
Received on April 14, 1992; accepted on May 8, 1992
In recent years, several glycosyltransferase genes and cDNAs have been cloned and characterized. Although the glycosyltransferases seem to share the same general architecture, there is only little sequence similarity between the various enzymes. Moreover, a comparison of the organization of the genes shows that there is no common pattern of intron-exon structure. In addition, there seems to be little or no correlation between glycosyltransferase exons and protein domains. Taken together, these observations suggest that many of the glycosyltransferase genes evolved independently. So far, only two glycosyltransferase gene families have been described. These families may have evolved by exon-shuffling, or by gene duplication and subsequent divergence. For specific glycosyltransferases, mechanisms such as alternative splicing and alternative promoter usage play a role in the production of multiple protein isoforms from a single gene. These isoenzymes may differ In their enzymatic properties or cellular localization.
genomic organization glycosyltransferases mammals protein structure
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  B. P. Griffith, M. Haddad, and R. S. Poston Immunobiology of Heart and Heart-Lung Transplantation Card. Surg. Adult, January 1, 2008; 3(2008): 1513 - 1538. [Full Text]
|
|
|
|
 |
|
 K. Nguyen, I. van Die, K. M Grundahl, Z. S Kawar, and R. D Cummings Molecular cloning and characterization of the Caenorhabditis elegans {alpha}1,3-fucosyltransferase family Glycobiology, June 1, 2007; 17(6): 586 - 599. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Schon, C. Prante, C. Bahr, J. Kuhn, K. Kleesiek, and C. Gotting Cloning and Recombinant Expression of Active Full-length Xylosyltransferase I (XT-I) and Characterization of Subcellular Localization of XT-I and XT-II J. Biol. Chem., May 19, 2006; 281(20): 14224 - 14231. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Kotani, S. Kitazume, K. Kamimura, S. Takeo, T. Aigaki, H. Nakato, and Y. Hashimoto Characterization of Drosophila Aspartic Proteases That Induce the Secretion of a Golgi-Resident Transferase, Heparan Sulfate 6-O-Sulfotransferase J. Biochem., March 1, 2005; 137(3): 315 - 322. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Gotting, S. Muller, M. Schottler, S. Schon, C. Prante, T. Brinkmann, J. Kuhn, and K. Kleesiek Analysis of the DXD Motifs in Human Xylosyltransferase I Required for Enzyme Activity J. Biol. Chem., October 8, 2004; 279(41): 42566 - 42573. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Akimoto, H. Kawakami, K. Yamamoto, E. Munetomo, T. Hida, and H. Hirano Elevated Expression of O-GlcNAc-Modified Proteins and O-GlcNAc Transferase in Corneas of Diabetic Goto-Kakizaki Rats Invest. Ophthalmol. Vis. Sci., September 1, 2003; 44(9): 3802 - 3809. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. P. Griffith and R. S. Poston Immunobiology of Heart and Heart-Lung Transplantation Card. Surg. Adult, January 1, 2003; 2(2003): 1403 - 1426. [Full Text]
|
|
|
|
|
|
M. Lanteri, V. Giordanengo, F. Vidal, P. Gaudray, and J.-C. Lefebvre A complete {alpha}1,3-galactosyltransferase gene is present in the human genome and partially transcribed Glycobiology, December 1, 2002; 12(12): 785 - 792. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. D. Lazarus, J. Milland, P. A. Ramsland, E. Mouhtouris, and M. S. Sandrin Histidine 271 has a functional role in pig {alpha}-1,3galactosyltransferase enzyme activity Glycobiology, December 1, 2002; 12(12): 793 - 802. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Milland, S. M. Russell, H. C. Dodson, I. F. C. McKenzie, and M. S. Sandrin The Cytoplasmic Tail of alpha 1,3-Galactosyltransferase Inhibits Golgi Localization of the Full-length Enzyme J. Biol. Chem., March 15, 2002; 277(12): 10374 - 10378. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. J. Miller, X. Shi, and H. Burkin Molecular Basis of Mammalian Gamete Binding Recent Prog. Horm. Res., January 1, 2002; 57(1): 37 - 73. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. McCormick, G. Duncan, K. T. Goutsos, and F. Tufaro The putative tumor suppressors EXT1 and EXT2 form a stable complex that accumulates in the Golgi apparatus and catalyzes the synthesis of heparan sulfate PNAS, January 18, 2000; 97(2): 668 - 673. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Xu, T. Storch, M. Yu, S. P. Elliott, and D. B. Haslam Characterization of the Human Forssman Synthetase Gene. AN EVOLVING ASSOCIATION BETWEEN GLYCOLIPID SYNTHESIS AND HOST-MICROBIAL INTERACTIONS J. Biol. Chem., October 8, 1999; 274(41): 29390 - 29398. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Leiter, J. Mucha, E. Staudacher, R. Grimm, J. Glossl, and F. Altmann Purification, cDNA Cloning, and Expression of GDP-L-Fuc:Asn-linked GlcNAc alpha 1,3-Fucosyltransferase from Mung Beans J. Biol. Chem., July 30, 1999; 274(31): 21830 - 21839. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Ge, N. W. C. Chan, M. M. Palcic, and D. E. Taylor Cloning and Heterologous Expression of an alpha 1,3-Fucosyltransferase Gene from the Gastric Pathogen Helicobacter pylori J. Biol. Chem., August 22, 1997; 272(34): 21357 - 21363. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Whitehouse, J. Burchell, S. Gschmeissner, I. Brockhausen, K. O. Lloyd, and J. Taylor-Papadimitriou A Transfected Sialyltransferase That Is Elevated in Breast Cancer and Localizes to the medial/trans-Golgi Apparatus Inhibits the Development of core-2-based O-Glycans J. Cell Biol., June 16, 1997; 137(6): 1229 - 1241. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Weinstein, S. Sundaram, X. Wang, D. Delgado, R. Basu, and P. Stanley A Point Mutation Causes Mistargeting of Golgi GlcNAc-TV in the Lec4A Chinese Hamster Ovary Glycosylation Mutant J. Biol. Chem., November 1, 1996; 271(44): 27462 - 27469. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Furukawa, H. Soejima, N. Niikawa, H. Shiku, and K. Furukawa Genomic Organization and Chromosomal Assignment of the Human beta 1,4-N-Acetylgalactosaminyltransferase Gene. IDENTIFICATION OF MULTIPLE TRANSCRIPTION UNITS J. Biol. Chem., August 23, 1996; 271(34): 20836 - 20844. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Kitagawa, M.-G.èv. Mattei, and J. C. Paulson Genomic Organization and Chromosomal Mapping of the Galbeta1,3GalNAc/Galbeta1,4GlcNAc alpha2,3-Sialyltransferase J. Biol. Chem., January 12, 1996; 271(2): 931 - 938. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Altmann, H. Schwihla, E. Staudacher, J. Glössl, and L. März Insect Cells Contain an Unusual, Membrane-bound [IMAGE]-N-Acetylglucosaminidase Probably Involved in the Processing of Protein N-Glycans J. Biol. Chem., July 21, 1995; 270(29): 17344 - 17349. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Kozarov, H. van der Wel, M. Field, M. Gritzali, R. D. Brown Jr., and C. M. West Characterization of FP21, a Cytosolic Glycoprotein from Dictyostelium J. Biol. Chem., February 17, 1995; 270(7): 3022 - 3030. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M F Bierhuizen, M G Mattei, and M Fukuda Expression of the developmental I antigen by a cloned human cDNA encoding a member of a beta-1,6-N-acetylglucosaminyltransferase gene family. Genes & Dev., March 1, 1993; 7(3): 468 - 478. [Abstract] [PDF]
|
|
|
|
|
|
J. Kuhn, C. Gotting, M. Schnolzer, T. Kempf, T. Brinkmann, and K. Kleesiek First Isolation of Human UDP-D-Xylose: Proteoglycan Core Protein beta -D-Xylosyltransferase Secreted from Cultured JAR Choriocarcinoma Cells J. Biol. Chem., February 9, 2001; 276(7): 4940 - 4947. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Milland, S. G. Taylor, H. C. Dodson, I. F. C. McKenzie, and M. S. Sandrin The Cytoplasmic Tail of alpha 1,2-Fucosyltransferase Contains a Sequence for Golgi Localization J. Biol. Chem., April 6, 2001; 276(15): 12012 - 12018. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Kremer, L. G. Dover, C. Morehouse, P. Hitchin, M. Everett, H. R. Morris, A. Dell, P. J. Brennan, M. R. McNeil, C. Flaherty, et al. Galactan Biosynthesis in Mycobacterium tuberculosis. IDENTIFICATION OF A BIFUNCTIONAL UDP-GALACTOFURANOSYLTRANSFERASE J. Biol. Chem., July 6, 2001; 276(28): 26430 - 26440. [Abstract] [Full Text] [PDF]
|
|