Skip Navigation


Glycobiology Advance Access originally published online on April 23, 2009
Glycobiology 2009 19(8):829-833; doi:10.1093/glycob/cwp058
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplementary Data
Right arrow All Versions of this Article:
19/8/829    most recent
cwp058v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (1)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Condac, E.
Right arrow Articles by Hinsdale, M. E
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Condac, E.
Right arrow Articles by Hinsdale, M. E
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2009. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Communication

Xylosyltransferase II is a significant contributor of circulating xylosyltransferase levels and platelets constitute an important source of xylosyltransferase in serum

Eduard Condac2, George L Dale4, Diane Bender-Neal5, Beatrix Ferencz2, Rheal Towner6 and Myron E Hinsdale1,2,3

2 Department of Physiological Sciences, Oklahoma State University, Stillwater, OK 74078
3 Department of Cell Biology
4 Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104
5 Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599
6 Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA

1 To whom correspondence should be addressed: Tel: +1-405-744-8103; Fax: +1-405-744-6263; e-mail Myron.Hinsdale{at}okstate.edu

Received on January 14, 2009; revised on March 24, 2009; accepted on April 15, 2009

Circulating glycosyltransferases including xylosyltransferases I (XylT1) and II (XylT2) are potential serum biomarkers for various diseases. Understanding what influences the serum activity of these enzymes as well as the sources of these enzymes is important to interpreting the significance of alterations in enzyme activity during disease. This article demonstrates that in the mouse and human the predominant XylT in serum is XylT2. Furthermore, that total XylT levels in human serum are approximately 200% higher than those in plasma due in part to XylT released by platelets during blood clotting in vitro. In addition, the data from Xylt2 knock-out mice and mice with liver neoplasia show that liver is a significant source of serum XylT2 activity. The data presented suggest that serum XylT levels may be an informative biomarker in patients who suffer from diseases affecting platelet and/or liver homeostasis.

Key words: glycosyltransferase / liver / platelets / proteoglycans / serum


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.