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Glycobiology Advance Access originally published online on August 20, 2009
Glycobiology 2009 19(11):1248-1258; doi:10.1093/glycob/cwp120
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© The Author 2009. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Galectin-3 regulates peritoneal B1-cell differentiation into plasma cells

Felipe L Oliveira2, Roger Chammas3, Lauremília Ricon2, Marise L Fermino4, Emerson S Bernardes4, Daniel K Hsu5, Fu-Tong Liu5, Radovan Borojevic2 and Márcia C El-Cheikh1,2

2 Laboratório de Proliferação e Diferenciação Celular, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro
3 Laboratório de Oncologia Experimental and Instituto do Câncer do Estado de São Paulo, Faculdade de Medicina de Universidade de São Paulo and Centre for Cell-Based Therapy CEPID-FAPESP, São Paulo
4 Laboratório de Glicobiologia e Imunoquímica, Departamento de Biologia Celular e Molecular e Bioagentes Patogênicos, Faculdade de Medicina, USP, Ribeirão Preto, SP, Brazil
5 Department of Dermatology, School of Medicine, University of California, Davis, Sacramento, CA, USA

1 To whom correspondence should be addressed: Tel: +55-21-25626483; Fax: +55-21-25626483; e-mail: marcia{at}histo.ufrj.br

Received on June 5, 2009; revised on August 7, 2009; accepted on August 12, 2009

Extracellular galectin-3 participates in the control of B2 lymphocyte migration and adhesion and of their differentiation into plasma cells. Here, we analyzed the role of galectin-3 in B1-cell physiology and the balance between B1a and B1b lymphocytes in the peritoneal cavity. In galectin-3–/– mice, the total number of B1a lymphocytes was lower, while B1b lymphocyte number was higher as compared to wild-type mice. The differentiation of B1a cells into plasma cells was associated with their abnormal adhesion and location on the mesentery. The B220 and CD43, constitutively expressed by B1 lymphocytes, were respectively up- and downregulated in galectin-3–/– mice. Mononuclear cells were strongly adhered to the mesenteric membranes of both CD43–/– and galectin-3–/– mice, but in contrast to CD43–/– mice, the accumulation of B1 cells in peritoneal membranes in galectin-3–/– mice was accompanied by their functional differentiation into plasma cells. We have shown that in the absence of galectin-3, B1-cell differentiation into plasma cells is favored and the dynamic equilibrium of B1-cell populations in the peritoneum is maintained through a compensatory increase in B1b lymphocytes.

Key words: B1 lymphocytes / galectin-3 / plasma cell / peritoneal cavity


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