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Glycobiology Advance Access originally published online on June 5, 2008
Glycobiology 2008 18(9):719-726; doi:10.1093/glycob/cwn051
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© The Author 2008. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Disruption of thymopoiesis in ST6Gal I-deficient mice

Julie H Marino2, Chibing Tan2, Brenda Davis2, Eun-Soo Han5, Morgan Hickey5, Rebecca Naukam2, Ashlee Taylor2, Kenton S Miller5, C Justin Van De Wiele2 and T Kent Teague1,2,3,4

2 Department of Surgery, University of Oklahoma College of Medicine, Tulsa, OK 74135, USA
3 Department of Pharmaceutical Sciences, University of Oklahoma College of Pharmacy, Tulsa, OK 74135, USA
4 Department of Biochemistry and Microbiology, Oklahoma State University Center for Health Sciences, Tulsa, OK 74127, USA
5 Department of Biological Sciences, University of Tulsa, Tulsa, OK 74104, USA

1 To whom correspondence should be addressed: Tel: +1-918-660-3920; Fax: +1-918-660-3928; e-mail: kent-teague{at}ouhsc.edu

Received on March 31, 2008; revised on May 18, 2008; accepted on May 28, 2008

Thymocyte development is accompanied by sequential changes in cell surface glycosylation. For example, medullary thymocytes have increased levels of {alpha}2,3-linked sialic acid and a loss of asialo core 1 O-glycans as compared to cortical thymocytes. Some of these changes have been linked to fine tuning of the T cell receptor avidity. We analyzed ST6Gal I transcript abundance and levels of {alpha}2,6-linked sialic acid across thymocyte subsets. We found that ST6Gal I transcript levels increased following T cell receptor β-selection suggesting that this sialyltransferase may influence the development of early thymocyte populations. Indeed, low levels of {alpha}2,6-linked sialic acid were found in the earliest T lineage cells, and then increased in T cell receptor β-selected cells. To determine whether ST6Gal I influences T cell development, we analyzed ST6Gal I-deficient mice for disruptions in thymocyte populations. We found reduced thymic cellularity in the ST6Gal I-deficient mice starting in the early thymocyte compartments.

Key words: sialic acid / ST6Gal I / thymocyte development


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