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Glycobiology Advance Access originally published online on May 28, 2008
Glycobiology 2008 18(9):679-685; doi:10.1093/glycob/cwn046
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© The Author 2008. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Communication

Human and mouse macrophage-inducible C-type lectin (Mincle) bind Candida albicans

Andrea Bugarcic2, Kelly Hitchens3, Anthony G Beckhouse3, Christine A Wells3, Robert B Ashman4 and Helen Blanchard1,2

2 Institute for Glycomics, Griffith University, Gold Coast Campus, QLD 4222, Australia
3 National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, QLD 4111, Australia
4 School of Dentistry, The University of Queensland, Brisbane, QLD 4072, Australia

1 To whom correspondence should be addressed: Tel: +61-7-555-27023; Fax: +61-7-555-28098; e-mail: h.blanchard{at}griffith.edu.au

Received on March 26, 2008; revised on May 15, 2008; accepted on May 21, 2008

Candida albicans is a causative agent in mycoses of the skin, oral cavity, and gastrointestinal tract. Identification of receptors, and their respective ligands, that are engaged by immune cells when in contact with C. albicans is crucial for understanding inflammatory responses leading to invasive candidiasis. Mincle is a recently identified macrophage-expressed receptor that is important for host responses to C. albicans. The carbohydrate-recognition domain of human and mouse Mincle were expressed, purified under denaturing conditions, and successfully refolded. In addition to oligomers, there are isolatable monomeric and dimeric forms of the protein that occur under two different buffer solutions. The human and mouse homologues bound yeast extract, and the isolated dimeric and monomeric species also demonstrated the recognition of whole C. albicans yeast cells. The data are indicative of several functional states mediating the interaction of Mincle and yeast at the surface of the macrophage.

Key words: Candida albicans / C-type lectin / Mincle / receptor-binding assay


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