Skip Navigation


Glycobiology Advance Access originally published online on May 23, 2007
Glycobiology 2007 17(8):795-804; doi:10.1093/glycob/cwm053
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
17/8/795    most recent
cwm053v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Rogerio, A. P
Right arrow Articles by Faccioli, L. H
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rogerio, A. P
Right arrow Articles by Faccioli, L. H
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2007. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Anti-asthmatic potential of a D-galactose-binding lectin from Synadenium carinatum latex

Alexandre P Rogerio2, Cristina R Cardoso3, Caroline Fontanari4, Maria A Souza5, Sandra R Afonso-Cardoso5, Érika VG Silva4, Natalia S Koyama3, Fernanda L Basei2, Edson G Soares3, João B Calixto2, Sean R Stowell6, Marcelo Dias-Baruffi1,4 and Lúcia H Faccioli1,4

2 Centro de Ciências Biológicas, Campus Universitário Trindade, Universidade Federal de Santa Catarina, Florianópolis, SC 88049-900, Brazil
3 Faculdade de Medicina de Ribeirão Preto
4 Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Av. do Café s/n, Ribeirão Preto, SP 14040-903, Brazil
5 Instituto de Ciências Biomédicas, Universidade Federal de Uberlândia, Av. Pará, 1720, Bloco 4C, Campus Umuarama, Uberlândia, MG 38400-902, Brazil
6 Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322

1 To whom correspondence should be addressed; Tel: +55 16 3602 4303; Fax: +55 16 3602 4725; E-mail: faccioli{at}fcfrp.usp.br, mdbaruff{at}fcfrp.usp.br

Received on May 24, 2006; revised on April 4, 2007; accepted on May 9, 2007

Extracts from the plant Synadenium carinatum latex are widely and indiscriminately used in popular medicine to treat a great number of inflammatory disorders and although the mechanisms underlying these effects remain undefined, the lectin isolated from S. carinatum latex (ScLL) is thought to be in part responsible for these anti-inflammatory effects. In order to elucidate possible immunoregulatory activities of ScLL, we investigated the effects of ScLL administration in models of acute and chronic inflammation. Oral administration of ScLL significantly inhibited neutrophil and eosinophil extravasation in models of acute and chronic inflammation and reduced eosinophil and mononuclear blood counts during chronic inflammation. ScLL administration reduced IL(interleukin)-4 and IL-5 levels but increased interferon-{gamma} and IL-10 in an asthma inflammatory model, which suggested that it might induce a TH2 to TH1 shift in the adaptive immune response. ScLL also inhibited I{kappa}B{alpha} degradation, a negative regulator of proinflammatory NF-{kappa}B. Taken together, these results provide the first description of a single factor isolated from S. carinatum latex extract with immunoregulatory functions and suggest that ScLL may be useful in the treatment of allergic inflammatory disorders.

Key words: anti-inflammatory / asthma / immune response / lectin / Synadenium carinatum


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.