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Glycobiology Advance Access originally published online on May 4, 2006
Glycobiology 2006 16(8):113R-136R; doi:10.1093/glycob/cwj125
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© The Author 2006. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

REVIEW

Glycopeptides as versatile tools for glycobiology

Therese Buskas, Sampat Ingale and Geert-Jan Boons1

Complex Carbohydrate Research Center, University of Georgia, 315 Riverbend Road, Athens, GA

1 To whom correspondence should be addressed; e-mail: gjboons{at}ccrc.uga.edu

This review describes the recent advances in the field of glycopeptide and small glycoprotein synthesis. The strategies covered include chemical and chemoenzymatic synthesis, native chemical ligation (NCL), and expressed chemical ligation. The importance of glycopeptide synthesis is exemplified by giving the reader an overview of how versatile and important these well-defined glycopeptides are as tools in glycobiology.

Key words: glycobiology / glycopeptides / glycoproteins / oligosaccharide / synthesis


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