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Glycobiology Advance Access originally published online on November 30, 2005
Glycobiology 2006 16(3):39R-45R; doi:10.1093/glycob/cwj059
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© The Author 2005. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

REVIEW

Meet the multifunctional and sexy glycoforms of glycodelin

Kfir Lapid2 and Nathan Sharon1,3

2 Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel; and 3 Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot 76100, Israel

1 To whom correspondence should be addressed; e-mail: nathan.sharon{at}weizmann.ac.il

Glycodelin, a human-secreted glycoprotein that appears in a small number of glycoforms, exhibits diverse biological activities, such as in contraception and immunosuppression. Moreover, different tissue-specific glycoforms appear to mediate diverse functions. Quite unusually, the glycodelin N-linked glycans differ between the male and female glycoforms. The fact that these glycans are fundamental for exerting the physiological activities of the different glycoforms, makes them an interesting target for glycobiology research. This review will focus on the involvement of the glycans in glycodelin activity and compare between the several glycoforms.

Key words: contraception / glycans / immunosuppression / oocyte / sperm


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