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Glycobiology Advance Access originally published online on December 23, 2003
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Glycobiology vol 14 no 4 pp. 357-363, 2004
Glycobiology vol. 14 no. 4 © Oxford University Press 2004; all rights reserved.

Galectin-1 induces astrocyte differentiation, which leads to production of brain-derived neurotrophic factor

Tasuku Sasaki3, Jun Hirabayashi2,4, Hiroshi Manya3, Ken-ichi Kasai4 and Tamao Endo1,3

3 Glycobiology Research Group, Tokyo Metropolitan Institute of Gerontology, Foundation for Research on Aging and Promotion of Human Welfare, 35-2 Sakaecho, Itabashi-ku, Tokyo 173-0015, Japan; and 4 Department of Biological Chemistry, Faculty of Pharmaceutical Sciences, Teikyo University, Sagamiko, Kanagawa 199-0195, Japan

Received on November 12, 2003; revised on November 30, 2003; accepted on December 4, 2003

Brain-derived neurotrophic factor (BDNF) is a neuroprotective polypeptide that is thought to be responsible for neuron proliferation, differentiation, and survival. An agent that enhances production of BDNF is expected to be useful for the treatment of neurodegenerative diseases. Here we report that galectin-1, a member of the family of ß-galactoside binding proteins, induces astrocyte differentiation and strongly inhibits astrocyte proliferation, and then the differentiated astrocytes greatly enhance their production of BDNF. Induction of astrocyte differentiation and BDNF production by an endogenous mammalian lectin may be a new mechanism for preventing neuronal loss after injury.

2 Present address: Glycostructure Analysis Team, Research Center for Glycoscience, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba Central 6, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8566, Japan

1 To whom correspondence should be addressed; e-mail: endo{at}tmig.or.jp


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