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Glycobiology Advance Access originally published online on December 23, 2003
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Glycobiology vol 14 no 3 pp. 1R-15R, 2004
Glycobiology vol. 14 no. 3 © Oxford University Press 2004; all rights reserved.

REVIEW

Biosynthesis of 6-deoxyhexose glycans in bacteria

Minna Mäki2 and Risto Renkonen1,2,3

2 Rational Drug Design Program and Department of Bacteriology and Immunology, Biomedicum and Haartman Institute, PO Box 63, FIN-00014 University of Helsinki, Helsinki, Finland; 3 HUCH Laboratory Diagnostics, Helsinki University Central Hospital, PO Box 401, FIN-00029 HUCH, Helsinki, Finland

Received on September 12, 2003; revised on October 18, 2003; accepted on November 25, 2003

After the breakthroughs in genomic sequencing, one of the next challenges remains to understand the molecular biology of other classes of biomolecules, such as protein and lipids, many of which carry specific glycomodification when mediating their biological functions. This review focuses on the 6-deoxyhexose biosynthesis of cell surface glycans of three Gram-negative pathogens, Helicobacter pylori, Pseudomonas aeruginosa, and Actinobacillus actinomycetemcomitans serotype a. 6-Deoxysugars are important functional components of cell surface glycans, and their biosynthetic pathways might be suitable targets for novel interventions of antibacterial chemotherapy.

1 To whom correspondence should be addressed; e-mail: risto.renkonen{at}helsinki.fi


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