Glycobiology Advance Access originally published online on September 9, 2003
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Glycobiology, 2003, Vol. 13, No. 12 1C-5C
© 2003 Oxford University Press
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A new superfamily of protein-O-fucosyltransferases, 
2-fucosyltransferases, and 6-fucosyltransferases: phylogeny and identification of conserved peptide motifs
2 Unité de Glycobiologie et Signalisation Cellulaire, INSERM U504, GDR CNRS 2590, Université de Paris Sud XI, 16 Ave Paul Vaillant-Couturier, 94807 Villejuif Cedex France, and 3 CERMAV-CNRS, BP 53, 38041 Grenoble Cedex 9, France
Received on July 9, 2003; accepted on August 14, 2003
The presence of three conserved peptide motifs shared by 
2-fucosyltransferases, 6-fucosyltransferases, the protein-O-fucosyltransferase family 1 (POFUT1) and a newly identified protein-O-fucosyltransferase family 2 (POFUT2), together with evidence that the present genes encoding for these enzymes have originated from a common ancestor by duplication and divergent evolution, suggests that they constitute a new superfamily of fucosyltransferases.
1 To whom correspondence should be addressed; e-mail: oriol{at}vjf.inserm.fr
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