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Glycobiology, 2002, Vol. 12, No. 9 545-553
© 2002 Oxford University Press

Tumor-related expression of {alpha}1,2fucosylated antigens on colorectal carcinoma cells and its suppression by cell-mediated priming using sugar acceptors for {alpha}1,2fucosyltransferase

Shin Yazawa1,2, Toyo Nishimura2, Munenori Ide3, Takayuki Asao3, Akihiko Okamura3, Susumu Tanaka2, Izumi Takai2, Yuko Yagihashi2, Abby R. Saniabadi2 and Naohisa Kochibe4

2 Japan Immunoresearch Laboratories, 351-1 Nishiyokote-cho, Takasaki 370-0021, Japan; 3 1st Department of Surgery, Gunma University School of Medicine, Maebashi, Japan; and 4 Department Biology, Faculty of Education, Gunma University, Maebashi, Japan

The accumulation of {alpha}1,2fucosylated antigens, such as Y (Fuc{alpha}1,2Galß1,4 [Fuc{alpha}1,3]GlcNAcß), Leb (Fuc{alpha}1,2Galß1,3-[Fuc{alpha}1,4]GlcNAcß), and H type 2 (Fuc{alpha}1,2 Galß1,4GlcNAcß) occurs specifically within human colorectal tumor tissues and can be detected by an antifucosylated antigen antibody, such as the YB-2 antibody. In the present investigation, we found that the expression of these antigens bearing an {alpha}1,2-linked fucose correlated with the resistance of the tumor cells to anticancer treatments. Addition of an exogenous sugar acceptor for {alpha}1,2fucosyltransferase to the cell medium resulted in suppression of {alpha}1,2fucosylated antigen expression on the tumor cells and increased susceptibility to anticancer treatment. The increased susceptibility may be attributed to cancer cell–mediated priming by sugar acceptors for {alpha}1,2fucosyltransferase added to the medium.

1 To whom correspondence should be addressed; E-mail: syazawa{at}po.sphere.ne.jp


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