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Glycobiology, 2002, Vol. 12, No. 6 69R-77R
© 2002 Oxford University Press

MINI REVIEW

Recent advances in the chemical synthesis of mucin-like glycoproteins

Lisa A. Marcaurelle and Carolyn R. Bertozzi1

Center for New Directions in Organic Synthesis, Departments of Chemistry and Molecular and Cell Biology, and Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA

Abstract

This purpose of this mini review is to familiarize readers with the tools currently available for the synthesis of mucin-type glycoproteins. The article will highlight recent approaches to the synthesis of glycopeptide fragments bearing complex O-linked glycans, as well as new strategies for the generation of full-length glycoproteins.

Footnotes

1 To whom correspondence should be addressed; E-mail: bertozzi{at}cchem.berkeley.edu


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