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Glycobiology, 2002, Vol. 12, No. 5 339-344
© 2002 Oxford University Press

Effects of the mono- and tetrasialogangliosides GM1 and GQ1b on ATP-induced long-term potentiation in hippocampal CA1 neurons

Satoshi Fujii1,2, Kotaro Igarashi2, Hiroshi Sasaki2, Hidekazu Furuse2, Ken-ichi Ito2, Kenya Kaneko2, Hiroshi Kato2, Jin-ichi Inokuchi3, Hatsue Waki4 and Susumu Ando4

2 Department of Physiology, Yamagata University School of Medicine, Yamagata 990-9585, Japan; 3 Department of Biomembrane and Biofunctional Chemistry, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan; and 4 Department of Membrane Biochemistry, Tokyo Metropolitan Institute for Gerontology, Sacaecho, Itabashi-ku, Tokyo 173-0015, Japan

The effects of the mono- and tetrasialogangliosides, GM1 and GQ1b, on ATP-induced long-term potentiation (LTP) were studied in CA1 neurons of guinea pig hippocampal slices. Application of 5 or 10 µM ATP for 10 min resulted in a transient depression followed by a slow augmentation of synaptic transmission, leading to LTP. LTP induced by treatment with 5 µM ATP was facilitated in hippocampal slices prepared from animals treated for 6 days with a ceramide analog, L-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propranol, which stimulates ganglioside biosynthesis. In addition, LTP induced by 5 µM ATP was significantly enhanced when naive slices were incubated with GQ1b but not with GM1. These results suggest that a cooperative effect between extracellular ATP and GQ1b enhances ATP-induced LTP in hippocampal CA1 neurons. In addition, the LTP induced by 10 µM ATP was blocked by coapplication of the NMDA antagonist AP5 (5 µM or 50 µM), and this effect was partially inhibited by GQ1b pretreatment of the slices, suggesting that in hippocampal CA1 neurons, the enhancing effect of GQ1b on ATP-induced LTP is mediated by modulation of NMDA receptors/Ca2+ channels.

1 To whom correspondence should be addressed


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