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Glycobiology, 2002, Vol. 12, No. 2 129-134
© 2002 Oxford University Press

Galectin-3 is strongly up-regulated in nonapoptosing mammary epithelial cells during rat mammary gland involution

Jörg Mengwasser2, Fu-Tong Liu3 and Jonathan P. Sleeman1,2

2Forschungszentrum Karlsruhe, Institute for Toxicology and Genetics, PO Box 3640, D-76021 Karlsruhe, Germany, and 3Division of Allergy, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA

Galectin-3 is an endogenous mammalian lectin that binds to ABH carbohydrate antigens. Here we show that galectin-3 is strongly up-regulated during mammary gland involution and that it is expressed virtually exclusively on nonapoptotic cells. We demonstrate that dexamethasone, an inhibitor of the second phase of mammary gland involution, potently suppresses up-regulation of galectin-3 as judged immunohistochemically and on western blots, suggesting that systemic hormone levels regulate galectin-3 expression during involution. However, at the RNA level galectin-3 expression is rapidly up-regulated on the onset of involution but remains consistantly high during the first and second phase of involution regardless of dexamethasone treatment. These data suggest that the up-regulation of galectin-3 in the involuting mammary gland is not only controlled transcriptionally but also regulated posttranscriptionally under the control of systemic glucocorticoid hormones involved in coordinating the involution process.

1 To whom correspondence should be addressed


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