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Glycobiology, 2001, Vol. 11, No. 5 71R-79R
© 2001 Oxford University Press

MINI REVIEW

Lectin-like proteins in model organisms: implications for evolution of carbohydrate-binding activity

Roger B. Dodd1 and Kurt Drickamer2

Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK

Abstract

Classes of intracellular lectins that recognize core-type structures and mediate intracellular glycoprotein trafficking are present in vertebrates, model invertebrates such as Caenorhabditis elegans and Drosophila melanogaster, plants, and yeasts. Lectins that recognize more complex structures at the cell surface, such as C-type lectins and galectins, are also found in invertebrate organisms as well as vertebrates, but the functions of these proteins have evolved differently in different animal lineages.

Footnotes

1 Present address: Wellcome Trust Centre for the Study of Molecular Mechanisms in Disease, Cambridge University, Wellcome Trust/MRC Building, Hills Road, Cambridge CB2 2XY, UK

2 To whom correspondence should be addressed


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