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Glycobiology, 2001, Vol. 11, No. 2 131-139
© 2001 Oxford University Press

Structure and properties of the exopolysaccharide produced by Streptococcus macedonicus Sc136

Sébastien J.F. Vincent1, Elisabeth J. Faber2, Jean-Richard Neeser, Francesca Stingele and Johannis P. Kamerling2

Nestlé Research Center, Vers-chez-les-Blanc, CH-1000 Lausanne 26, Switzerland, and 2Bijvoet Center, Department of Bio-Organic Chemistry, Utrecht University, P.O. Box 80.075, NL-3508 TB Utrecht, The Netherlands

Streptococcus macedonicus is a Gram positive lactic acid bacterium that is part of the starter flora present in Greek sheep and goat cheeses. The S. macedonicus Sc136 strain produces a high-molecular-mass, highly texturizing exopolysaccharide composed of D-glucose, D-galactose, and N-acetyl-D-glucosamine in the molar ratio of 3:2:1. The structure of the exopolysaccharide produced by S. macedonicus Sc136 was determined by chemical analysis, mass spectrometry, and nuclear magnetic resonance spectroscopy. The repeating unit was shown to be:


The polysaccharide sidechain ß-D-Galf-(1->6)-ß-D-Glcp-(1->6)-ß-D-GlcpNAc is a key factor in the highly texturizing properties of the S.macedonicus Sc136 exopolysaccharide. Finally, the trisaccharide sequence ß-D-GlcpNAc-(1->3)-ß-D-Galp-(1->4)-ß-D-Glcp corresponds to the internal backbone of the lacto-N-tetraose and lacto-N-neotetraose units, which serve as a structural basis for the large majority of human milk oligosaccharides, an additional property offering an important potential for the development of improved infant nutrition products.

1 To whom correspondence should be addressed


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