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Glycobiology, 2000, Vol. 10, No. 9 849-856
© 2000 Oxford University Press

MINI REVIEW Carbohydrate sulfotransferases in lymphocyte homing

Stefan Hemmerich1 and Steven D. Rosen2

Department of Respiratory Diseases, Roche Bioscience, 3401 Hillview Ave., Palo Alto, CA 94304-1397, USA and 2Department of Anatomy, Program in Immunology and Cardiovascular Research Institute, University of California, San Francisco, CA 94143-0452, USA

Sulfation is a critical modification in many instances of biological recognition. Early work in lymphocyte homing indicated that the endothelial ligands for L-selectin depended upon sulfation modifications. Subsequent studies showed that the two specific modifications, Gal-6-SO4 and GlcNAc-6-SO4, were present on actual biological ligands. Recently, a family of carbohydrate sulfotransferases capable of generating these modifications has been identified at the molecular level. Reconstitution experiments implicate members of this family as critical participants in lymphocyte homing.

1 To whom correspondence should be addressed


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